Common Variants in One-Carbon Metabolism Genes (MTHFR, MTR, MTHFD1) and Depression in Gynecologic Cancers

We investigated the association between methylenetetrahydrofolate reductase (gene MTHFR 677C>T, rs1801133), 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR 2756A>G, rs1805087), and dehydrogenase, cyclohydrolase formyltetrahydrofolate synthetase 1 MTHFD1 1958G>A, rs2236225)—well-studied functional variants involved in one-carbon metabolism—and gynecologic cancer risk, interaction these polymorphisms depression. A total of 200 cases 240 healthy controls were recruited to participate this study. Three single-nucleotide (SNVs) (rs1801133, rs1805087, rs2236225) genotyped using PCR-restriction fragment length polymorphism method. Depression was assessed all patients Hamilton Scale. statistically significantly more frequent women with cancers (69.5% vs. 34.2% controls, p < 0.001). rs2236225 associated an increased risk (in dominant OR = 1.53, 0.033, log-additive models 1.37, 0.024). Moreover, found depression rs1801133 genotypes but not codominant model CC TT: 3.39, 95%: 1.49–7.74, 0.011). Cancers female reproductive system are occurrence depression, ovarian may be variant gene. In addition, aging Polish population, gene is